我們是一個藉由比較物種或個體間基因體 (genome)的差異，探討物種遺傳演化及寄生機制的實驗室。研究內容為分析第二或第三世代定序技術 (Second/Third generation sequencing) 產生的巨量基因體資訊來做物種間的比較及族群分析。研究材料著重於醫學，林業，農業，畜牧業，及台灣生態環境上有重要地位的真菌及線蟲。主要研究方向如下：
- 次世代定序技術 (Next generation sequencing) 分析及相關新實驗的設計
The principal objective of our research lies in the fundamental mechanisms and evolution or pathogenicity and parasitism. We are mainly interested in fungi and nematodes that are of medical, agricultural, forestry, and Taiwan biodiversity importance.
Comparative population genomics of microbes in nature
Evolution and biology of microbial life cycle dynamics
Although vast amounts of information are being gathered from the various genome projects on similarities and differences between species that are very different to each other, virtually nothing is known about differences at the genomic level between individuals from the same species or from very closely related species. Yet such variability forms the basis for evolutionary change. One of our main focuses of was to quantify the life cycle of microbes undergoing different modes of reproduction in nature. Measures of DNA sequence variation as a result of fundamental cellular processes at different stages of life cycle, for example, mutation and recombination, were calculated. Some of these variations are influenced by processes that only occur in certain stages of the life cycle.
Evolution of parasitic pathogens
Recognizing that important pathogens still lag far behind in terms of genome research compared to model species, we started developing informatics tools with the aim of building up genomic resources to provide analysis tools both for my own research and for the wider research community.